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KMID : 1144820220280030145
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대한의생명과학회지
2022 Volume.28 No. 3 p.145 ~ p.156
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Applications of MALDI-TOF Mass Spectrometry in Clinical Microbiology
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Shin Kyeong-Seob
Yum Jong-Hwa
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Abstract
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Over the past few decades, few technologies have had a greater impact on clinical microbiology laboratories than matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF MS). The MALDI-TOF MS is a fast, accurate, and low-cost and efficient method of microbial identification. This technology generates characteristic mass spectral fingerprints that is a unique signature for each microorganism, making it an ideal method for accurate identification at the genus and species levels of both bacterial and fastidious microorganism such as anaerobes, mycobacterium and fungi etc. In addition, MALDI-TOF MS has been successfully used in microbial subtyping and susceptibility tests such as determination of resistance genes. In this study, the authors summarized the application of MALDI-TOF MS in clinical microbiology and clinical research and explored the future of MALDI-TOF MS.
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KEYWORD
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MALDI-TOF MS, Clinical microbiology, Application, Identification, Subtyping, Susceptibility
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